טכניון מכון טכנולוגי לישראל
הטכניון מכון טכנולוגי לישראל - בית הספר ללימודי מוסמכים  
M.Sc Thesis
M.Sc StudentBen-Yehuda Maya
SubjectDevelopment of Nanometric platform for the Delivery of
Hydrophobic Compounds
DepartmentDepartment of Chemical Engineering
Supervisors Professor Havazelet Bianco-Peled
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Full Thesis textFull thesis text - English Version


Abstract

Inspired by the need to overcome the poor water solubility of hydrophobic drugs, such as doxurubicin, paclitaxel and everolimus. A novel nanoparticle preparation method - solvent exchange method was developed.  Nanoparticles composed of Polyvinylpyrrolidone and hydrophobic model drugs were formed and characterized by Dynamic Light Scattering, Small angle X-ray scattering and Cryo- Transmission electron microscopy. Encapsulation efficiency was measured and calculated to be high by UV spectroscopy. These nanocarriers were found to be highly stable in Sodium Chloride solutions, In vitro experiments show that nanoparticles formulation composed of the polymer Polyvinylpyrrolidone and a model drug molecule the dye, Nile red were able to penetrate into cells. The method was proved to be generic by changing model drug molecule with different hydrophobic molecules and by changing solvent to different solvents.