|M.Sc Student||Kovachi Tchelet|
|Subject||Structure-Activity Relationships of Acyl-Lysine Oligomers|
|Department||Department of Biotechnology and Food Engineering||Supervisor||Professor Amram Mor|
|Full Thesis text|
C12K-3b10 resembles previously characterized OAKs with respect to activities against gram negative bacteria and red blood cells, but is also active against gram positive bacteria. The data suggest moreover that the OAK might act by distinct mechanisms on distinct bacteria. The effect of C12K-3b10 at sub-MIC concentrations combined with conventional antibiotics against both Staphylococcus aureus and Escherichia coli varied from full synergy through re-sensitization up to no effect at all, depending on various factors such as bacterial species and antibiotics used. This suggests that depending on the bacterial envelop, the OAK enables increased antibiotic penetrability and thus may help overcome some resistance mechanisms against them. Overall, these properties suggest that C12K-3β10 might represent a potential candidate for therapeutic development.