טכניון מכון טכנולוגי לישראל
הטכניון מכון טכנולוגי לישראל - בית הספר ללימודי מוסמכים  
Ph.D Thesis
Ph.D StudentBlumer-Ganon Batya
SubjectElectrooptic Amino Acids and Peptides
DepartmentDepartment of Chemistry
Supervisor Professor Yoav Eichen
Full Thesis text - in Hebrew Full thesis text - Hebrew Version


Abstract

Many new organic compounds are synthesized daily and new applications using them often found. Theoretically, organic chemistry enables to prepare infinite number of different materials.  Synthesizing "suspicious" materials, testing them and adjusting them to our needs are the conventional method to prepare new compounds. This approach, can cause many difficulties due to the large amount of resources and time invested in each stage of the synthesis. The complexity of the end compound also dictates the number of stages needed to be studied and optimized and only then the properties of the material and its adjustment to the requirements is tested. 

In contrary, the biological realm presents numerous high-yield and sequence independent synthetic protocols. Nature can prepare large numbers of variants of molecules, screening them by their functionality and performance. The two main biological families of complex supramolecular structures are the phosphodiester world, which contains all the polynucleic acids such as DNA and RNA, and the peptide world, which contains all the polypeptides such as proteins and enzymes.

Peptides are bio-molecules formed from the interconnection of two or more amino acids. Using such a single linker unit will enable the construction of large molecules or polymers with arbitrary, yet well-defined, sequence. Nature utilizes 20 known amino acids in order to obtain the entire verity of proteins and enzymes exist. Each protein has a specific structure and function depending on the amino acids sequence.

Construction of material libraries and searching them in order to discover the suitable compound with the precise structural mechanical, optical and other properties is an attempt to mimic the nature's technique to synthesis new materials. Sequence independent synthesis is one line of approaching this task. Due to the importance of two of these reactions, nucleic acid chemistry and peptide chemistry to the field of molecular biology, two most powerful in-vitro synthetic protocols were developed for the preparation of peptide and nucleic acid sequences, both in solutions and on solid supports.

In the first chapter we report on the preparation of electroactive amino acids and oligopeptides and on the investigation of some of their optical, electrochemical and charge-transport properties. The electronic and electrooptic functionality of these materials is examined in an organic light emitting diodes configuration.

In the second chapter we report on detectors for cation based on electroactive amino acids and oligopeptide. We prepared 4 detectors and examine there luminescence changes using protons, zinc and uranil cations.