|M.Sc Student||Gantman Marina|
|Subject||Mapping of Sites within the Tetrahymena Telomerase|
Catalytic Subunit that Interact with DNA Primers
in Telomerase Elongation Complexes
|Department||Department of Biology||Supervisors||Professor Haim Manor|
|Professor Emeritus Dan Cassel|
|Full Thesis text - in Hebrew|
Telomeres are DNA-protein complexes found at the ends o linier eukaryotic chromosomes. These complexes protect the chromosomes from degradation and fusion with other chromosomes. Telomerase is a reverse transcriptase that uses an integral RNA molecule as a template for elongating the telomeric DNA. In addition to the RNA subunit, the telomerase core enzyme contains a protein subunit designated TERT. My research focused on mapping the interactions of the telomeric DNA with TERT in an active enzyme. My study revealed a new interaction with the amino acid residue phenyl alanine #192 in TERT.