M.Sc Thesis

M.Sc StudentArad Alumah
SubjectSolubility of Respiratory Gases in Aqueous
DepartmentDepartment of Chemical Engineering
Supervisors PROFESSOR EMERITUS Moshe Sheintuch
Full Thesis textFull thesis text - English Version


Solubilities of respiratory gases in water and aqueous solutions were rigorously explored by solution thermodynamics. This study focused on seven gases important in diving and hyperbaric treatment: oxygen, nitrogen, carbon dioxide, helium, hydrogen, neon and argon. The main goals were to determine whether deviations from Henry's Law are significant, to quantify the effects of blood solutes on gas solubility and to examine the possible contribution of equilibrium thermodynamics to physiological isobaric supersaturation.

The model of respiratory gas mixture solubility in plasma and blood under extreme physiological conditions was developed by the following main stages: a single gas in water, gas mixtures in water and effects of blood solutes on solubility. The model incorporates Krichevsky-Kasarnovsky Equation, Clarke-Glew Equation, Trebble-Bishnoi-Salim Equation of State and Schumpe's model. Comparison to scarce experimental data showed good to excellent prediction ability.

Mutual effects of respiratory gases were thoroughly explored by Ruckenstein and Shulgin's method of multicomponent composition prediction, which is based on the Kirkwood and Buff Fluctuation Theory of Solutions. Trebble-Bishnoi-Salim Equation of State was applied with Huron-Vidal mixing rules. A thermodynamic contribution to the physiological adverse effect known as counterdiffusion was found.

Solubilities of respiratory gas mixtures in plasma were calculated for actual conditions of experimental dives and hyperbaric therapy. Effects of solubility behavior on the physiological response to extreme conditions were deduced.