Subject: Subject Sylbus: Structures and Design in Biomacromolecules - 136093

Structures and Design in Biomacromolecules - 136093
Given In
  Lecture Exercise Laboratory Project or

Determination of the grade according to progress during the semester and the submission of the final thesis

Prerequisites: ( Physical Chemistry 124510
and Metabolic Pathways 134113 )
or ( Physical Chemistry 124510
and Introduction to Biochemistry and Enzymology 134019 )
Linked Courses: General Genetics 134020
Overlapping Courses: Structure and Function of Macromolecules 138093

The Chemistry of Macromolecules, Different Levels of Protein Structure, Mapping the Protein Universe, Principles Forces in Protein Folding, Why Is Double-Stranded Dna Helical, What Came First Protein Sequence Or Structure. Designability Principle. Simulating Macromolecular Structures, Kinetics of Protein Folding. Experimental Methods for Studying Folding. Protein Engineering and Design. in Vitro Evolution of Novel Proteins from Scratch. Principles of Designig Ideal Protein Structures. Disordered Proteins and Natively Unfolded Proteins. the Role of Water in the Structure and Function of Module, Students Should Be Able to:
1. Understand the Basic Forces That Shape Both Proteins and Nucleic Acids Structure. What Mutations Do for a Protein Structure and How to Go About Designing Them for Specific Purposes.
2. Understand What Determines Protein Folding and Stability.
3. Understand the Versatility of Natively Unfolded Proteins - What They Are Good for and Why.
4. Understand Ab Initio Rational Desig Principles of Protein Form Scratch and from Pre-Existing Folds, Towards Synthetic Biology.
5. Read and Understnad Current Primary Paper Written on Protein Folding and Design, Sufficiently to Present the Subject Orally and Write a Term Paper on It.

System of hours to the semesters
Semester Previous Semester information 01/2017 2017/2018 Winter Semester

1993 t.e creightonproteins: structure and molecular properties
1998 k.e van holde w.c. johnson and p.s. hoprinciples of physical biochemistry

Created in 21/01/2018 Time 20:22:04