טכניון מכון טכנולוגי לישראל
הטכניון מכון טכנולוגי לישראל - בית הספר ללימודי מוסמכים  
Ph.D Thesis
Ph.D StudentOhana David
SubjectDehydroepiandrosterone Improves Mood and Decision-Making
of Polydrug Abusers during Rehabilitation and
Decreases Subsequent Relapse
DepartmentDepartment of Industrial Engineering and Management
Supervisors Professor Eldad Yechiam
Professor Gal Yadid
Full Thesis textFull thesis text - English Version


Abstract

The main goal of the current study was to examine whether the administration of DHEA would be an effective add-on to detoxification treatment enriched with intensive psychosocial services and aftercare. Using a double blind placebo-controlled study, we examined for the first time the effect of DHEA treatment on mood, decision making, and relapse into drug usage up to 16 months after leaving the rehabilitation center. 121 multi-drug addicted patients from 2 rehabilitation centers were volunteered. The treatment was orally administered to the study participants for 6 consecutive months in doses of 100 mg/day. Further psychological assessments and blood samples were collected at baseline, after 1, 4.5 and 6 months (end-of-study). Due to the attrition after the 1 month session, we focused on results taken at or before this time point; as well as on the follow-up report. DHEA had a positive effect on abstinence approximately 16 months after leaving the rehabilitation center. Furthermore, the administration of DHEA seemed to act as an equalizer which negated the effect of variance in the involvement in the relevant activities on relapse. Moreover, after 1 month DHEA improved decision making performance. Finally, DHEA in combination with enriched environment improved reported quality of life. In light of these findings, we suggest to include DHEA treatment build-in rehabilitation centers treatments with environmental enrichment in which patients are exposed during their staying in rehabilitation center.