טכניון מכון טכנולוגי לישראל
הטכניון מכון טכנולוגי לישראל - בית הספר ללימודי מוסמכים  
M.Sc Thesis
M.Sc StudentShiran Shultz
SubjectPolymers for Trapping Materials
DepartmentDepartment of Polymer Engineering
Supervisors Professor Szpilman Alex.m
Full Professor Eisen Moris
Full Thesis textFull thesis text - English Version


Abstract

Renal failure is a situation in which the kidneys fail to function properly. Since the kidneys play a key role in humans body function, not only by filtering the blood and disposing of waste products, but also by balancing levels of electrolytes such as phosphorus in the body, controlling blood pressure, and stimulating the production of red blood cells, their lack of function may lead to a very serious medical condition. There are two main types of renal failure: acute and chronic. Acute renal failure (ARF) is a sudden and temporary loss of the kidneys function and chronic renal failure (CRF) develops over months and years. The different renal failure derives from diverse causes.

The treatment provided to patients suffering from renal failure is dialysis or kidney transplant. In case of ARF dialysis is used to help the kidneys temporarily until they recover. In CRF patients the dialysis treatment is necessary in order to keep them alive. Dialysis provides an artificial replacement for the loss of the kidneys due to renal failure. The main purpose of the dialysis procedure is to remove organic waste, products of breakdown that the body undergoes, excess of electrolytes, and therefore begin the correction of salt, water and acid-base abnormal levels.

In spite of hemodialysis being a proven and rather sufficient treatment for chronic kidney failure, the survival of dialysis patients still remains poor, especially because of an increase in the cardiovascular risk. It should be noted that none of the various types of dialysis available today operate at the exact rhythm as normal kidneys do. Various studies carried out in the last few years point out that more frequent and prolonged dialysis treatment can be connected with remarkably improved outcomes in those patients.

The aim of this research is to focus on one electrolyte among many that the dialysis does not succeed in removing adequately enough- inorganic phosphate, and to try to improve its secretion from the body by binding it to a specific ligand and attach it to an insoluble polymer that will be used as a scaffold suited to the physical conditions; temperature and pH. These polymers could be used to regenerate the dialysate solution- the solution that is being used today in the process of dialysis, by providing a significant step towards the development of a wearable artificial kidney, which could improve the quality of life for millions of people.