טכניון מכון טכנולוגי לישראל
הטכניון מכון טכנולוגי לישראל - בית הספר ללימודי מוסמכים  
M.Sc Thesis
M.Sc StudentGerchikov Yulia
SubjectPreparation and Characterization of Luiminescent Systems
for the Detection of Nucleophiles
DepartmentDepartment of Chemistry
Supervisor Professor Yoav Eichen
Full Thesis text - in Hebrew Full thesis text - Hebrew Version


Abstract

The human body is sensitive to the inhalation of diverse gaseous substances (referred to as "toxic gases"). These gasses can be classified into many families, one of which are nucleophiles. The main goal of this research is to apply PET-based luminescence turn-on systems and processes for the detection of nucleophiles in solutions and in the gas phase. According to the PET concept the sensing molecule contains a luiminiphore and a quencher attached to each other in a way that prevents luminescence. Upon reaction with the electrophile, the quencher is disabled and luuminescence is regained.

This research addressed four different issues.           

a) The preparation and characterization of systems for the detection of different nucleophilic species. The reaction of the novel systems with different nucleophilic species was tested. Upon the reaction with a nucleophile an enhancement of the luiminecense was determined.

b) Study of the reaction kinetics of sensing systems with different nucleophiles. The reaction rate was the indication for nucleophiles strength. The results were compared with the Swain and Scott scale.

c) Study of the role e of counter ion in the reaction. We examined the effect of different counter ions of chloride on the reaction rate with one of the sensing system.

d) Demonstration of real sensing ability using a simple solid supported sensor array.